The phenomenon of catabolite repression enables microorganisms to use their favourite carbon source first. New work reveals α-ketoacids as key effectors of this process, with their levels regulating gene expression. See Article p.301
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Efficient lipidomic approach for the discovery of lipid ligands for immune receptors by combining LC-HRMS/MS analysis with fractionation and reporter cell assay
Analytical and Bioanalytical Chemistry Open Access 23 December 2023
-
Protocol: a fast, comprehensive and reproducible one-step extraction method for the rapid preparation of polar and semi-polar metabolites, lipids, proteins, starch and cell wall polymers from a single sample
Plant Methods Open Access 10 November 2016
-
Current status and future perspectives of kinetic modeling for the cell metabolism with incorporation of the metabolic regulation mechanism
Bioresources and Bioprocessing Open Access 11 February 2015
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
*This article and the paper under discussion3 were published online on 7 August 2013.
References
Maaløe, O. in Biological Regulation and Development (ed. Goldberger, R. F.) 487–542 (Plenum, 1979).
Klumpp, S., Zhang, Z. & Hwa, T. Cell 139, 1366–1375 (2009).
You, C. et al. Nature 500, 301–306 (2013).
Monod, J. Recherches sur la croissance des cultures bactériennes. PhD thesis (Univ. Paris, 1942).
Jacob, F. & Monod, J. J. Mol. Biol. 3, 318–356 (1961).
Makman, R. S. & Sutherland, E. W. J. Biol. Chem. 240, 1309–1314 (1965).
Emmer, M., deCrombrugghe, B., Pastan, I. & Perlman, R. Proc. Natl Acad. Sci. USA 66, 480–487 (1970).
Zubay, G., Schwartz, D. & Beckwith, J. Proc. Natl Acad. Sci. USA 66, 104–110 (1970).
Deutscher, J., Francke, C. & Postma, P. W. Microbiol. Mol. Biol. Rev. 70, 939–1031 (2006).
Magasanik, B. Cold Spring Harb. Symp. Quant. Biol. 26, 249–256 (1961).
Bennett, B. D. et al. Nature Chem. Biol. 5, 593–599 (2009).
Mandelstam, J. Nature 179, 1179–1181 (1957).
Daniel, J. & Danchin, A. Biochimie 68, 303–310 (1986).
Doucette, C. D., Schwab, D. J., Wingreen, N. S. & Rabinowitz, J. D. Nature Chem. Biol. 7, 894–901 (2011).
Inada, T., Kimata, K. & Aiba, H. Genes Cells 1, 293–301 (1996).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rabinowitz, J., Silhavy, T. Metabolite turns master regulator. Nature 500, 283–284 (2013). https://doi.org/10.1038/nature12544
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature12544
This article is cited by
-
Efficient lipidomic approach for the discovery of lipid ligands for immune receptors by combining LC-HRMS/MS analysis with fractionation and reporter cell assay
Analytical and Bioanalytical Chemistry (2023)
-
The remodel of the “central dogma”: a metabolomics interaction perspective
Metabolomics (2021)
-
Protocol: a fast, comprehensive and reproducible one-step extraction method for the rapid preparation of polar and semi-polar metabolites, lipids, proteins, starch and cell wall polymers from a single sample
Plant Methods (2016)
-
Normalization and integration of large-scale metabolomics data using support vector regression
Metabolomics (2016)
-
Current status and future perspectives of kinetic modeling for the cell metabolism with incorporation of the metabolic regulation mechanism
Bioresources and Bioprocessing (2015)
