Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Computational biology

A recipe for ligand-binding proteins

Cellular cross-talk, enzymatic catalysis and regulation of gene expression all depend on molecular recognition. A method that allows the design of proteins with desired recognition sites could thus be revolutionary. See Letter p.212

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Steps to making a ligand-binding protein.

Notes

  1. *This article and the paper under discussion1 were published online on 4 September 2013.

References

  1. Tinberg, C. E. et al. Nature 501, 212–216 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Gebauer, M. & Skerra, A. Meth. Enzymol. 503, 157–188 (2012).

    Article  CAS  Google Scholar 

  3. Gilbreth, R. N. & Koide, S. Curr. Opin. Struct. Biol. 22, 413–420 (2012).

    Article  CAS  Google Scholar 

  4. Jiang, L. et al. Science 319, 1387–1391 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Siegel, J. B. et al. Science 329, 309–313 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Röthlisberger, D. et al. Nature 453, 190–195 (2008).

    Article  ADS  Google Scholar 

  7. Privett, H. K. et al. Proc. Natl Acad. Sci. USA 109, 3790–3795 (2012).

    Article  ADS  CAS  Google Scholar 

  8. Korendovych, I. V. et al. Org. Lett. 12, 5142–5145 (2010).

    Article  CAS  Google Scholar 

  9. Schreirer, B., Stumpp, C., Wiesner, S. & Höcker, B. Proc. Natl Acad. Sci. USA 106, 18491–18496 (2009).

    Article  ADS  Google Scholar 

  10. Metz, S. et al. Proc. Natl Acad. Sci. USA 108, 8194–8199 (2011).

    Article  ADS  CAS  Google Scholar 

  11. Jeffrey, P. D. et al. Proc. Natl Acad. Sci. USA 90, 10310–10314 (1993).

    Article  ADS  CAS  Google Scholar 

  12. Korndörfer, I. P., Schlehuber, S. & Skerra, A. J. Mol. Biol. 330, 385–396 (2003).

    Article  Google Scholar 

  13. Fowler, D. M. et al. Nature Meth. 7, 741–746 (2010).

    Article  CAS  Google Scholar 

  14. Koide, S. & Sidhu, S. S. ACS Chem. Biol. 4, 325–334 (2009).

    Article  CAS  Google Scholar 

  15. Koga, N. et al. Nature 491, 222–227 (2012).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giovanna Ghirlanda.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ghirlanda, G. A recipe for ligand-binding proteins. Nature 501, 177–178 (2013). https://doi.org/10.1038/nature12463

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12463

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research