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Biochemistry

Curbing the excesses of low demand

Nature volume 500, pages 157–158 (2013)Cite this article

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Metabolic processes are regulated by the relative need for the end product, but this control mechanism may fail if demand is very low. A safety mechanism that copes with low demand has been discovered in bacteria. See Letter p.237

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Figure 1: Regulating metabolite production.

Notes

  1. *This article and the paper under discussion1 were published online on 31 July 2013.

References

  1. Reaves, M. L., Young, B. D., Hosios, A. M., Xu, Y.-F. & Rabinowitz, J. D. Nature 500, 237–241 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Umbarger, H. E. Science 123, 848 (1956).

    Article  ADS  CAS  Google Scholar 

  3. Yates, R. A. & Pardee, A. B. J. Biol. Chem. 221, 757–770 (1956).

    CAS  PubMed  Google Scholar 

  4. Hofmeyr, J.-H. S. Essays Biochem. 45, 57–66 (2008).

    Article  CAS  Google Scholar 

  5. Boy, E. & Patte, J.-C. J. Bact. 112, 84–92 (1972).

    Article  CAS  Google Scholar 

  6. Hofmeyr, J.-H. S. & Cornish-Bowden, A. FEBS Lett. 476, 47–51 (2000).

    Article  CAS  Google Scholar 

  7. Cárdenas, M. L. “Glucokinase”: Its Regulation and Role in Liver Metabolism (Landes Bioscience, 1995).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Athel Cornish-Bowden is at Bioénergétique et Ingénierie des Protéines, Institut de Microbiologie de la Méditerranée, CNRS Aix-Marseille Université, BP 71, 13402 Marseille Cedex 20, France.,

    Athel Cornish-Bowden

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  1. Athel Cornish-Bowden
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Correspondence to Athel Cornish-Bowden.

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Cornish-Bowden, A. Curbing the excesses of low demand. Nature 500, 157–158 (2013). https://doi.org/10.1038/nature12461

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