The gene variant APOE4 is the most common genetic risk factor associated with late-onset Alzheimer's disease. A comprehensive, multilayer study reveals the molecular and cellular signatures of APOE4 in humans. See Article p.45
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*This article and the paper under discussion1 were published online on 24 July 2013.
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Swarup, V., Geschwind, D. From big data to mechanism. Nature 500, 34–35 (2013). https://doi.org/10.1038/nature12457
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