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Cell biology

Tumour stem cells in bone

Activation of the signalling molecule SHP2 is implicated in driving several cancers. In a newly described class of bone-progenitor cells, however, it seems that the protein acts as a tumour suppressor. See Letter p.491

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Figure 1: Regulation of chondrocyte formation.


  1. *This article and the paper under discussion1 were published online on 17 July.


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Correspondence to Mone Zaidi or Simón Méndez-Ferrer.

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Zaidi, M., Méndez-Ferrer, S. Tumour stem cells in bone. Nature 499, 414–416 (2013).

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