Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neuroscience

Stem cells in multiple time zones

In fruitfly larvae, neural stem cells generate different cell types at different times. It emerges that these temporal progressions are controlled by multiple cascades of gene transcription factors. See Articles p.449 & p.456

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Time-dependent evolution of neural lineage trees.

Notes

  1. 1.

    *This article and the papers under discussion7,8 were published online on 19 June 2013.

References

  1. 1

    Jacob, J., Maurange, C. & Gould, A. P. Development 135, 3481–3489 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Okano, H. & Temple, S. Curr. Opin. Neurobiol. 19, 112–119 (2009).

    CAS  Article  Google Scholar 

  3. 3

    Pearson, B. J. & Doe, C. Q. Annu. Rev. Cell Dev. Biol. 20, 619–647 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Brody, T. & Odenwald, W. F. Dev. Biol. 226, 34–44 (2000).

    CAS  Article  Google Scholar 

  5. 5

    Gaspard, N. et al. Nature 455, 351–357 (2008).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Shen, Q. et al. Nature Neurosci. 9, 743–751 (2006).

    CAS  Article  Google Scholar 

  7. 7

    Bayraktar, O. A. & Doe, C. Q. Nature 498, 449–455 (2013).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Li, X. et al. Nature 498, 456–462 (2013).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Baumgardt, M., Karlsson, D., Terriente, J., Díaz-Benjumea, F. J. & Thor, S. Cell 139, 969–982 (2009).

    CAS  Article  Google Scholar 

  10. 10

    Isshiki, T., Pearson, B., Holbrook, S. & Doe, C. Q. Cell 106, 511–521 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Kambadur, R. et al. Genes Dev. 12, 246–260 (1998).

    CAS  Article  Google Scholar 

  12. 12

    Maurange, C., Cheng, L. & Gould, A. P. Cell 133, 891–902 (2008).

    CAS  Article  Google Scholar 

  13. 13

    Novotny, T., Eiselt, R. & Urban, J. Development 129, 1027–1036 (2002).

    CAS  PubMed  Google Scholar 

  14. 14

    Guo, M., Jan, L. Y. & Jan, Y. N. Neuron 17, 27–41 (1996).

    Article  Google Scholar 

  15. 15

    Spana, E. P. & Doe, C. Q. Neuron 17, 21–26 (1996).

    CAS  Article  Google Scholar 

  16. 16

    Bello, B. C., Izergina, N., Caussinus, E. & Reichert, H. Neural Dev. 3, 5 (2008).

    Article  Google Scholar 

  17. 17

    Boone, J. Q. & Doe, C. Q. Dev. Neurobiol. 68, 1185–1195 (2008).

    Article  Google Scholar 

  18. 18

    Bowman, S. K. et al. Dev. Cell 14, 535–546 (2008).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Stefan Thor.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Thor, S. Stem cells in multiple time zones. Nature 498, 441–443 (2013). https://doi.org/10.1038/nature12261

Download citation

Search

Quick links