Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Ion channel twists to open

GIRK channels allow potassium ions to cross the cell membrane, thereby affecting the electrical status of the cell and so its functioning. Structural data now provide insight into the channels' mode of operation. See Article p.190

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The GIRK2 channel in action2.


  1. *This article and the paper under discussion2 were published online on 5 June 2013.


  1. Hibino, H. et al. Physiol. Rev. 90, 291–366 (2010).

    CAS  Article  Google Scholar 

  2. Whorton, M. R. & MacKinnon, R. Nature 498, 190–197 (2013).

    ADS  CAS  Article  Google Scholar 

  3. Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J. & Clapham, D. E. Nature 325, 321–326 (1987).

    ADS  CAS  Article  Google Scholar 

  4. Wickman, K. D. et al. Nature 368, 255–257 (1994).

    ADS  CAS  Article  Google Scholar 

  5. Reuveny, E. et al. Nature 370, 143–146 (1994).

    ADS  CAS  Article  Google Scholar 

  6. Lüscher, C. & Slesinger, P. A. Nature Rev. Neurosci. 11, 301–315 (2010).

    Article  Google Scholar 

  7. Rubinstein, M. et al. J. Physiol. (Lond.) 587, 3473–3491 (2009).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Eitan Reuveny.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Reuveny, E. Ion channel twists to open. Nature 498, 182–183 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing