Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Integration triggers death

That HIV cripples the immune system by killing CD4+ T cells has long been known. It now emerges that the protein DNA-PK, activated by viral integration into the host-cell genome, is the agent of this death response. See Letter p.376

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Opposing responses to DNA damage.


  1. *This article and the paper under discussion1 were published online on 5 June 2013.


  1. Cooper, A. et al. Nature 498, 376–379 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Vandegraaff, N., Kumar, R., Burrell, C. J. & Li, P. J. Virol. 75, 11253–11260 (2001).

    Article  CAS  Google Scholar 

  3. Ho, D. D. J. Clin. Invest. 99, 2565–2567 (1997).

    Article  CAS  Google Scholar 

  4. Li, L. et al. EMBO J. 20, 3272–3281 (2001).

    Article  CAS  Google Scholar 

  5. Skalka, A. M. & Katz, R. A. Cell Death Differ. 12, 971–978 (2005).

    Article  CAS  Google Scholar 

  6. Yang, J., Yu, Y., Hamrick, H. E. & Duerksen-Hughes, P. J. Carcinogenesis 24, 1571–1580 (2003).

    Article  CAS  Google Scholar 

  7. Daniel, R. et al. Mol. Cell. Biol. 21, 1164–1172 (2001).

    Article  CAS  Google Scholar 

  8. Lau, A., Kanaar, R., Jackson, S. P. & O'Connor, M. J. EMBO J. 23, 3421–3429 (2004).

    Article  CAS  Google Scholar 

  9. Hill, R. & Lee, P. W. K. Cell Cycle 9, 3460–3469 (2010).

    Article  CAS  Google Scholar 

  10. Shao, L., Goronzy, J. J. & Weyand, C. M. EMBO Mol. Med. 2, 415–427 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Anna Marie Skalka.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Skalka, A. Integration triggers death. Nature 498, 305–306 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing