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Integration triggers death

That HIV cripples the immune system by killing CD4+ T cells has long been known. It now emerges that the protein DNA-PK, activated by viral integration into the host-cell genome, is the agent of this death response. See Letter p.376

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Figure 1: Opposing responses to DNA damage.


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    *This article and the paper under discussion1 were published online on 5 June 2013.


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Correspondence to Anna Marie Skalka.

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Skalka, A. Integration triggers death. Nature 498, 305–306 (2013).

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