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The vector as protector

Malaria infections are not always lethal. One reason for this may be that transmission from mosquitoes creates malaria parasites that trigger a more protective mammalian immune response. See Letter p.228

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Figure 1: Evolutionary selection of antigenic profiles.


  1. *This article and the paper under discussion3 were published online on 29 May 2013.


  1. Mackinnon, M. J. & Marsh, K. Science 328, 866–871 (2010).

    ADS  CAS  Article  Google Scholar 

  2. Covell, G. & Nicol, W. D. Br. Med. Bull. 8, 51–58 (1951).

    CAS  Article  Google Scholar 

  3. Spence, P. J. et al. Nature 498, 228–231 (2013).

    ADS  CAS  Article  Google Scholar 

  4. Legrand, N. et al. Cell Host Microbe 6, 5–9 (2009).

    CAS  Article  Google Scholar 

  5. Langhorne, J., Ndungu, F. M., Sponaas, A.-M. & Marsh, K. Nature Immunol. 9, 725–732 (2008).

    CAS  Article  Google Scholar 

  6. Read, A. F., Day, T. & Huijben, S. Proc. Natl Acad. Sci. USA 108, 10871–10877 (2011).

    ADS  CAS  Article  Google Scholar 

  7. Ebbinghaus, P. & Krücken, J. Malaria J. 10, 272 (2011).

    CAS  Article  Google Scholar 

  8. Lawton, J. et al. BMC Genomics 13, 125 (2012).

    CAS  Article  Google Scholar 

  9. Mackinnon, M. J., Bell, A. & Read, A. F. Int. J. Parasitol. 35, 145–153 (2005).

    CAS  Article  Google Scholar 

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Correspondence to Andrew F. Read.

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Read, A., Mideo, N. The vector as protector. Nature 498, 177–178 (2013).

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