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Cancer

Drug for an 'undruggable' protein

Nature volume 497, pages 577–578 (2013)Cite this article

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Scientists have long aimed to develop drugs against the cancer-associated protein KRAS, but without success. An approach that targets the oncoprotein's cellular localization reignites lost enthusiasm. See Letter p.638

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Notes

  1. *This article and the paper under discussion2 were published online on 22 May 2013.

References

  1. Cox, A. D. & Der, C. J. Small GTPases 1, 2–27 (2010).

    Article  Google Scholar 

  2. Zimmermann, G. et al. Nature 497, 638–642 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Berndt, N., Hamilton, A. D. & Sebti, S. M. Nature Rev. Cancer 11, 775–791 (2011).

    Article  CAS  Google Scholar 

  4. Ahearn, I. M., Haigis, K., Bar-Sagi, D. & Philips, M. R. Nature Rev. Mol. Cell Biol. 13, 39–51 (2012).

    Article  CAS  Google Scholar 

  5. Philips, M. R. Nature Cell Biol. 14, 128–129 (2012).

    Article  CAS  Google Scholar 

  6. Nancy, V., Callebaut, I., El Marjou, A. & de Gunzburg, J. J. Biol. Chem. 277, 15076–15084 (2002).

    Article  CAS  Google Scholar 

  7. Ismail, S. A. et al. Nature Chem. Biol. 7, 942–949 (2011).

    Article  CAS  Google Scholar 

  8. Chandra, A. et al. Nature Cell Biol. 14, 148–158 (2012).

    Article  CAS  Google Scholar 

  9. Zhang, H. et al. Proc. Natl Acad. Sci. USA 104, 8857–8862 (2007).

    Article  ADS  CAS  Google Scholar 

  10. Laheru, D. et al. Invest. New Drugs 30, 2391–2399 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, Nicole M. Baker and Channing J. Der are in the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.,

    Nicole M. Baker & Channing J. Der

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  1. Nicole M. Baker
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  2. Channing J. Der
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Correspondence to Channing J. Der.

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Competing interests

C.J.D. has received honoraria from Bristol-Myers Squibb, Eli Lilly and Merck, and has a research contract with GlaxoSmithKline.

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Baker, N., Der, C. Drug for an 'undruggable' protein. Nature 497, 577–578 (2013). https://doi.org/10.1038/nature12248

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