How the enzyme diacylglycerol kinase can form membrane anchors and an active site from so few amino-acid residues has long been a mystery. Crystal structures reveal that it gets by with a little help from its friends. See Letter p.521
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*This article and the paper under discussion1 were published online on 15 May 2013.
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Zheng, J., Jia, Z. Tiny enzyme uses context to succeed. Nature 497, 445–446 (2013). https://doi.org/10.1038/nature12245
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