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Structural biology

Tiny enzyme uses context to succeed

How the enzyme diacylglycerol kinase can form membrane anchors and an active site from so few amino-acid residues has long been a mystery. Crystal structures reveal that it gets by with a little help from its friends. See Letter p.521

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Figure 1: A view of diacylglycerol kinase (DgkA).

Notes

  1. *This article and the paper under discussion1 were published online on 15 May 2013.

References

  1. Li, D. et al. Nature 497, 521–524 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Van Horn, W. D. & Sanders, C. R. Annu. Rev. Biophys. 41, 81–101 (2012).

    Article  CAS  Google Scholar 

  3. Taylor, S. S., Keshwani, M. M., Steichen, J. M. & Kornev, A. P. Phil. Trans. R. Soc. B 367, 2517–2528 (2012).

    Article  CAS  Google Scholar 

  4. Pieringer, R. A. & Kunnes, R. S. J. Biol. Chem. 240, 2833–2838 (1965).

    Article  CAS  Google Scholar 

  5. Badola, P. & Sanders, C. R. J. Biol. Chem. 272, 24176–24182 (1997).

    Article  CAS  Google Scholar 

  6. Van Horn, W. D. et al. Science 324, 1726–1729 (2009).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Zongchao Jia.

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Zheng, J., Jia, Z. Tiny enzyme uses context to succeed. Nature 497, 445–446 (2013). https://doi.org/10.1038/nature12245

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