Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

Tiny enzyme uses context to succeed

Nature volume 497, pages 445–446 (2013)Cite this article

Subjects

How the enzyme diacylglycerol kinase can form membrane anchors and an active site from so few amino-acid residues has long been a mystery. Crystal structures reveal that it gets by with a little help from its friends. See Letter p.521

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A view of diacylglycerol kinase (DgkA).

Notes

  1. *This article and the paper under discussion1 were published online on 15 May 2013.

References

  1. Li, D. et al. Nature 497, 521–524 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Van Horn, W. D. & Sanders, C. R. Annu. Rev. Biophys. 41, 81–101 (2012).

    Article  CAS  Google Scholar 

  3. Taylor, S. S., Keshwani, M. M., Steichen, J. M. & Kornev, A. P. Phil. Trans. R. Soc. B 367, 2517–2528 (2012).

    Article  CAS  Google Scholar 

  4. Pieringer, R. A. & Kunnes, R. S. J. Biol. Chem. 240, 2833–2838 (1965).

    Article  CAS  Google Scholar 

  5. Badola, P. & Sanders, C. R. J. Biol. Chem. 272, 24176–24182 (1997).

    Article  CAS  Google Scholar 

  6. Van Horn, W. D. et al. Science 324, 1726–1729 (2009).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jimin Zheng is in the College of Chemistry, Beijing Normal University, Beijing 100875, China.,

    Jimin Zheng

  2. Zongchao Jia is in the Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario K7L 3N6, Canada.,

    Zongchao Jia

Authors
  1. Jimin Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zongchao Jia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zongchao Jia.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zheng, J., Jia, Z. Tiny enzyme uses context to succeed. Nature 497, 445–446 (2013). https://doi.org/10.1038/nature12245

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12245

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing