Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Active arrestin proteins crystallized

Arrestin proteins regulate cellular signalling cascades initiated by ubiquitous G-protein-coupled receptors. Crystal structures reveal that two arrestins undergo similar structural changes on activation. See Letters p.137 & p.142

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Comparison of inactive and active arrestins.


  1. *This article and the papers under discussion1,2 were published online on 24 April 2013.


  1. Kim, Y. J. et al. Nature 497, 142–146 (2013).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Shukla, A. K. et al. Nature 497, 137–141 (2013).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  3. Palczewski, K. et al. Science 289, 739–745 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Granzin, J. et al. Nature 391, 918–921 (1998).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Hirsch, J. A., Schubert, C., Gurevich, V. V. & Sigler, P. B. Cell 97, 257–269 (1999).

    Article  CAS  PubMed  Google Scholar 

  6. Choe, H.-W. et al. Nature 471, 651–655 (2011).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Granzin, J. et al. J. Mol. Biol. 416, 611–618 (2012).

    Article  CAS  PubMed  Google Scholar 

  8. Han, M., Gurevich, V. V., Vishnivetskiy, S. A., Sigler, P. B. & Schubert, C. Structure 9, 869–880 (2001).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Georg Büldt.

Related links

Related links

Related links in Nature Research

NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family

Structural biology: Snapshot of a signalling complex

Cell signalling: Binding the receptor at both ends

Structural biology: A receptor unlocked

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Borshchevskiy, V., Büldt, G. Active arrestin proteins crystallized. Nature 497, 45–46 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing