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Genomics

Zebrafish earns its stripes

Nature volume 496, pages 443–444 (2013)Cite this article

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The reported sequence of the zebrafish genome, together with the production of mutant strains representing more than one-third of all its protein-coding regions, will accelerate the characterization of human genes. See Letters p.494 & p.498

Thousands of genes and gene variants are thought to contribute to human development, physiology and disease, but the functions of most of them are unknown. In the past 20 years, the zebrafish has emerged as a model system to investigate the function of human genes. Two papers in this issue1,2, reporting the sequence of the zebrafish genome and the isolation of disruptive mutations in more than 10,000 protein-coding genes, add to other recent studies3,4,5,6,7 in providing a strong boost to this effortFootnote 1.

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Figure 1: Linking phenotypes to genes.

Notes

  1. *This article and the papers under discussion1,2 were published online on 17 April 2013.

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  1. Alexander F. Schier is in the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.,

    Alexander F. Schier

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  1. Alexander F. Schier
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Correspondence to Alexander F. Schier.

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Schier, A. Zebrafish earns its stripes. Nature 496, 443–444 (2013). https://doi.org/10.1038/nature12094

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