Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuroscience

Anxiety is the sum of its parts

Nature volume 496, pages 174–175 (2013)Cite this article

Subjects

Anxiety does not arise from a single neural circuit. An interplay between neighbouring, yet opposing, circuits produces anxiety, and outputs from these circuits regulate specific anxiety responses. See Letters p.219 & p.224

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Multiple personalities of an anxiety circuit.

Notes

  1. *This article and the papers under discussion2,3 were published online on 20 March 2013.

References

  1. Kessler, R. C. et al. Arch. Gen. Psychiatry 62, 593–602 (2005).

    Article  Google Scholar 

  2. Jennings, J. H. et al. Nature 496, 224–228 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Kim, S.-Y. et al. Nature 496, 219–223 (2013).

    Article  ADS  CAS  Google Scholar 

  4. Davis, M., Walker, D. L., Miles, L. & Grillon, C. Neuropsychopharmacology 35, 105–135 (2010).

    Article  Google Scholar 

  5. Sullivan, G. M. et al. Neuroscience 128, 7–14 (2004).

    Article  CAS  Google Scholar 

  6. Duvarci, S., Bauer, E. P. & Pare, D. J. Neurosci. 29, 10357–10361 (2009).

    Article  CAS  Google Scholar 

  7. Poulos, A. M., Ponnusamy, R., Dong, H. W. & Fanselow, M. S. Proc. Natl Acad. Sci. USA 107, 14881–14886 (2010).

    Article  ADS  CAS  Google Scholar 

  8. Kudo, T. et al. J. Neurosci. 32, 18035–18046 (2012).

    Article  CAS  Google Scholar 

  9. Dong, H.-W. & Swanson, L. W. J. Comp. Neurol. 468, 277–298 (2004).

    Article  Google Scholar 

  10. Adhikari, A., Topiwala, M. A. & Gordon, J. A. Neuron 71, 898–910 (2011).

    Article  CAS  Google Scholar 

  11. Tye, K. M. et al. Nature 471, 358–362 (2011).

    Article  ADS  CAS  Google Scholar 

  12. Maren, S. & Quirk, G. J. Nature Rev. Neurosci. 5, 844–852 (2004).

    Article  CAS  Google Scholar 

  13. Herry, C. et al. Eur. J. Neurosci. 31, 599–612 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Joshua P. Johansen is at the RIKEN Brain Science Institute, Saitama 351-0198, Japan.,

    Joshua P. Johansen

Authors
  1. Joshua P. Johansen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Johansen, J. Anxiety is the sum of its parts. Nature 496, 174–175 (2013). https://doi.org/10.1038/nature12087

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12087

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing