Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

Painkillers caught in blood-cell trafficking

Haematopoietic stem and progenitor cells move from the bone marrow into the circulation to replenish normal blood-cell levels. Inhibiting a prostaglandin-mediated signalling pathway may promote this process. See Letter p.365

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: NSAIDs are gatekeepers of the haematopoietic microenvironment.


  1. *This article and the paper under discussion1 were published online on 13 March 2013.


  1. Hoggatt, J. et al. Nature 495, 365–369 (2013).

    CAS  ADS  Article  Google Scholar 

  2. Hoggatt, J., Singh, P., Sampath, J. & Pelus, L. M. Blood 113, 5444–5455 (2009).

    CAS  Article  Google Scholar 

  3. North, T. E. et al. Nature 447, 1007–1011 (2007).

    CAS  ADS  Article  Google Scholar 

  4. Bonig, H. & Papayannopoulou, T. Leukemia 27, 24–31 (2013).

    CAS  Article  Google Scholar 

  5. Hattori, K. et al. Nature Med. 8, 841–849 (2002).

    CAS  Article  Google Scholar 

  6. Goessling, W. et al. Cell Stem Cell 8, 445–458 (2011).

    CAS  Article  Google Scholar 

  7. Goessling, W. et al. Cell 136, 1136–1147 (2009).

    CAS  Article  Google Scholar 

  8. Hoggatt, J. & Pelus, L. M. Leukemia 24, 1993–2002 (2010).

    CAS  Article  Google Scholar 

  9. Butler, J. M. et al. Cell Stem Cell 6, 251–264 (2010).

    CAS  Article  Google Scholar 

  10. Hooper, A. T. et al. Cell Stem Cell 4, 263–274 (2009).

    CAS  Article  Google Scholar 

  11. Kobayashi, H. et al. Nature Cell Biol. 12, 1046–1056 (2010).10.1038/ncb2108

    CAS  Article  PubMed  Google Scholar 

  12. Butler, J. M. et al. Blood 120, 1344–1347 (2012).

    CAS  Article  Google Scholar 

  13. Heissig, B. et al. Cell 109, 625–637 (2002).

    CAS  Article  Google Scholar 

  14. Kimura, Y. et al. PLoS ONE 6, e26918 (2011).

    CAS  ADS  Article  Google Scholar 

  15. Ding, L. et al. Nature 481, 457–462 (2012).

    CAS  ADS  Article  Google Scholar 

  16. Ding, L. et al. Nature (2013).

  17. Jin, D. K. et al. Nature Med. 12, 557–567 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Shahin Rafii.

Related links

Related links

Related links in Nature Research

Painkillers mobilize blood stem cells

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Butler, J., Rafii, S. Painkillers caught in blood-cell trafficking. Nature 495, 317–318 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing