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Rubbing salt in the wound

The ability of sodium chloride to induce enzymatic activity that leads to the generation of pathogenic TH17 immune cells implicates salt as a possible factor that might exacerbate autoimmune disease. See Letters p.513 & p.518

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Figure 1: SGK1 and the differentiation of TH17 cells.


  1. *This article and the papers under discussion1,2 were published online on 6 March 2013.


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Correspondence to John J. O'Shea or Russell G. Jones.

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O'Shea, J., Jones, R. Rubbing salt in the wound. Nature 496, 437–439 (2013).

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