The ability of sodium chloride to induce enzymatic activity that leads to the generation of pathogenic TH17 immune cells implicates salt as a possible factor that might exacerbate autoimmune disease. See Letters p.513 & p.518
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Kleinewietfeld, M. et al. Nature 496, 518–522 (2013).
Wu, C. et al. Nature 496, 513–517 (2013).
Weaver, C. T., Hatton, R. D., Mangan, P. R. & Harrington, L. E. Annu. Rev. Immunol. 25, 821–852 (2007).
Stockinger, B., Veldhoen, M. & Martin, B. Semin.Immunol. 19, 353–361 (2007).
Kolls, J. K. & Linden, A. Immunity 21, 467–476 (2004).
Miossec, P. & Kolls, J. K. Nature Rev. Drug Discov. 11, 763–776 (2012).
Cua, D. J. et al. Nature 421, 744–748 (2003).
Sutton, C. E., Mielke, L. A. & Mills, K. H. G. Eur. J. Immunol. 42, 2221–2231 (2012).
Bruhn, M. A., Pearson, R. B., Hannan, R. D. & Sheppard, K. E. Growth Factors 28, 394–408 (2010).
Honda, K. & Littman, D. R. Annu. Rev. Immunol. 30, 759–795 (2012).
Dong, C., Davis, R. J. & Flavell, R. A. Annu. Rev. Immunol. 20, 55–72 (2002).
Wang, R. & Green, D. R. Nature Immunol. 13, 907–915 (2012).
Stockinger, B., Hirota, K., Duarte, J. & Veldhoen, M. Semin. Immunol. 23, 99–105 (2011).
About this article
Cite this article
O'Shea, J., Jones, R. Rubbing salt in the wound. Nature 496, 437–439 (2013). https://doi.org/10.1038/nature11959
This article is cited by
Nature Reviews Rheumatology (2017)