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Structural biology

Spliceosome's core exposed

The spliceosome complex removes intron sequences from RNA transcripts to form messenger RNA. The structure of a spliceosomal protein, Prp8, reveals the complex's active site and casts light on the origin of splicing. See Article p.638

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Figure 1: Model of the Prp8 structure.

Prp8 graphic courtesy of W. P. Galej, Medical Research Council, UK.

Notes

  1. *This article and the paper under discussion1 were published online on 23 January 2013.

References

  1. Galej, W. P., Oubridge, C., Newman, A. J. & Nagai, K. Nature 493, 638–643 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Grainger, R. J. & Beggs, J. D. RNA 11, 533–557 (2005).

    Article  CAS  Google Scholar 

  3. Sharp, P. A. Cell 42, 397–400 (1985).

    Article  CAS  Google Scholar 

  4. Cech, T. R. Cell 44, 207–210 (1986).

    Article  CAS  Google Scholar 

  5. Weber, G. et al. Genes Dev. 25, 1601–1612 (2011).

    Article  CAS  Google Scholar 

  6. Dlakić, M. & Mushegian, A. RNA 17, 799–808 (2011).

    Article  Google Scholar 

  7. Pena, V., Rozov, A., Fabrizio, P., Lührmann, R. & Wahl, M. C. EMBO J. 27, 2929–2940 (2008).

    Article  CAS  Google Scholar 

  8. Ritchie, D. B. et al. Nature Struct. Mol. Biol. 15, 1199–1205 (2008).

    Article  CAS  Google Scholar 

  9. Yang, K., Zhang, L., Xu, T., Heroux, A. & Zhao, R. Proc. Natl Acad. Sci. USA 105, 13817–13822 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Reyes, J. L., Gustafson, E. H., Luo, H. R., Moore, M. J. & Konarska, M. M. RNA 5, 167–179 (1999).

    Article  CAS  Google Scholar 

  11. Liu, L., Query, C. C. & Konarska, M. M. Nature Struct. Mol. Biol. 14, 519–526 (2007).

    Article  CAS  Google Scholar 

  12. Liu, L., Mushero, N., Hedstrom, L. & Gershenson, A. Biochemistry 45, 10865–10872 (2006).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Charles C. Query or Maria M. Konarska.

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Query, C., Konarska, M. Spliceosome's core exposed. Nature 493, 615–616 (2013). https://doi.org/10.1038/nature11857

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