Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Spliceosome's core exposed

The spliceosome complex removes intron sequences from RNA transcripts to form messenger RNA. The structure of a spliceosomal protein, Prp8, reveals the complex's active site and casts light on the origin of splicing. See Article p.638

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Model of the Prp8 structure.

Prp8 graphic courtesy of W. P. Galej, Medical Research Council, UK.


  1. *This article and the paper under discussion1 were published online on 23 January 2013.


  1. Galej, W. P., Oubridge, C., Newman, A. J. & Nagai, K. Nature 493, 638–643 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Grainger, R. J. & Beggs, J. D. RNA 11, 533–557 (2005).

    Article  CAS  Google Scholar 

  3. Sharp, P. A. Cell 42, 397–400 (1985).

    Article  CAS  Google Scholar 

  4. Cech, T. R. Cell 44, 207–210 (1986).

    Article  CAS  Google Scholar 

  5. Weber, G. et al. Genes Dev. 25, 1601–1612 (2011).

    Article  CAS  Google Scholar 

  6. Dlakić, M. & Mushegian, A. RNA 17, 799–808 (2011).

    Article  Google Scholar 

  7. Pena, V., Rozov, A., Fabrizio, P., Lührmann, R. & Wahl, M. C. EMBO J. 27, 2929–2940 (2008).

    Article  CAS  Google Scholar 

  8. Ritchie, D. B. et al. Nature Struct. Mol. Biol. 15, 1199–1205 (2008).

    Article  CAS  Google Scholar 

  9. Yang, K., Zhang, L., Xu, T., Heroux, A. & Zhao, R. Proc. Natl Acad. Sci. USA 105, 13817–13822 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Reyes, J. L., Gustafson, E. H., Luo, H. R., Moore, M. J. & Konarska, M. M. RNA 5, 167–179 (1999).

    Article  CAS  Google Scholar 

  11. Liu, L., Query, C. C. & Konarska, M. M. Nature Struct. Mol. Biol. 14, 519–526 (2007).

    Article  CAS  Google Scholar 

  12. Liu, L., Mushero, N., Hedstrom, L. & Gershenson, A. Biochemistry 45, 10865–10872 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Charles C. Query or Maria M. Konarska.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Query, C., Konarska, M. Spliceosome's core exposed. Nature 493, 615–616 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing