Nature 491, 364–373 (2012); doi:10.1038/nature11706

We inadvertently omitted to cite reference 101, which should have been cited on page 267 at the end of the following sentence: “Recent evidence suggests that renal cyst formation after Fh1 deletion is independent of HIF, but involves activation of the NRF2 pathway by fumarate, and that activation of NRF2 may contribute to the development of fumarate-hydratase-deficient cancers51,101.”