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Structural biology

Membrane enzyme cuts a fine figure

Malfunction of presenilin enzymes, which cleave proteins in cell membranes, can lead to Alzheimer's disease. A crystal structure of a microbial presenilin provides insights into the workings of this enzyme family. See Article p.56

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Figure 1: Architecture of a presenilin enzyme.

Notes

  1. 1.

    *This article and the paper under discussion4 were published online on 19 December 2012.

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Correspondence to Michael S. Wolfe.

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Wolfe, M. Membrane enzyme cuts a fine figure. Nature 493, 34–35 (2013). https://doi.org/10.1038/nature11768

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