The RNA-binding protein FMR1 has a key role in the neurodevelopmental disorder fragile X syndrome, but the RNAs targeted by the protein were mostly unknown. An analysis reveals thousands of possible targets. See Article p.382
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*This article and the paper under discussion1 were published online on 12 December 2012.
Ascano, M. Jr et al. Nature 492, 382–386 (2012).
Feng, Y. et al. Mol. Cell 1, 109–118 (1997).
Eberhart, D. E. & Warren, S. T. Somat. Cell Mol. Genet. 22, 435–441 (1996).
Vasudevan, S. & Steitz, J. A. Cell 128, 1105–1118 (2007).
Laggerbauer, B., Ostareck, D., Keidel, E. M., Ostareck-Lederer, A. & Fischer, U. Hum. Mol. Genet. 10, 329–338 (2001).
Bear, M. F., Huber, K. M. & Warren, S. T. Trends Neurosci. 27, 370–377 (2004).
Darnell, J. C. et al. Genes Dev. 19, 903–918 (2005).
Darnell, J. C. et al. Cell 146, 247–261 (2011).
Bassell, G. J. & Warren, S. T. Neuron 60, 201–214 (2008).
Hafner, M. et al. J. Vis. Exp. 41, e2034 (2010).
Jayaseelan, S., Doyle, F., Currenti, S. & Tenenbaum, S. A. Meth. Mol. Biol. 714, 407–422 (2011).
Keene, J. D., Komisarow, J. M. & Friedersdorf, M. B. Nature Protoc. 1, 302–307 (2006).
Tenenbaum, S. A., Lager, P. J., Carson, C. C. & Keene, J. D. Methods 26, 191–198 (2002).
Caudy, A. A., Myers, M., Hannon, G. J. & Hammond, S. M. Genes Dev. 16, 2491–2496 (2002).
Ishizuka, A., Siomi, M. C. & Siomi, H. Genes Dev. 16, 2497–2508 (2002).
Jin, P. et al. Nature Neurosci. 7, 113–117 (2004).
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Jayaseelan, S., Tenenbaum, S. Signalling pathways of fragile X syndrome. Nature 492, 359–360 (2012). https://doi.org/10.1038/nature11764
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