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Cell biology

Death by deacetylation

Necrosis is associated with various diseases, yet it is arguably the least-understood form of programmed cell death. It emerges that a sirtuin protein regulates one form of necrosis through a deacetylation reaction. See Article p.199

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Figure 1: Evolution of a death complex.


  1. *This article and the paper under discussion2 were published online on 28 November 2012.


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Correspondence to Junying Yuan.

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Zhou, W., Yuan, J. Death by deacetylation. Nature 492, 194–195 (2012).

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