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Cell biology

Death by deacetylation

Necrosis is associated with various diseases, yet it is arguably the least-understood form of programmed cell death. It emerges that a sirtuin protein regulates one form of necrosis through a deacetylation reaction. See Article p.199

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Figure 1: Evolution of a death complex.

Notes

  1. *This article and the paper under discussion2 were published online on 28 November 2012.

References

  1. Degterev, A. et al. Nature Chem. Biol. 1, 112–119 (2005).

    Article  CAS  Google Scholar 

  2. Narayan, N. et al. Nature 492, 199–204 (2012).

    Article  ADS  CAS  Google Scholar 

  3. Taylor, P. C. & Feldmann, M. Nature Rev. Rheumatol. 5, 578–582 (2009).

    Article  CAS  Google Scholar 

  4. Chowers, Y. & Allez, M. Curr. Drug Targets 11, 138–142 (2010).

    Article  CAS  Google Scholar 

  5. He, S. et al. Cell 137, 1100–1111 (2009).

    Article  CAS  Google Scholar 

  6. Cho, Y. S. et al. Cell 137, 1112–1123 (2009).

    Article  CAS  Google Scholar 

  7. Zhang, D. et al. Science 325, 332–336 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Milne, J. C. & Denu, J. M. Curr. Opin. Chem. Biol. 12, 11–17 (2008).

    Article  CAS  Google Scholar 

  9. Li, J. et al. Cell 150, 339–350 (2012).

    Article  CAS  Google Scholar 

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Correspondence to Junying Yuan.

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Zhou, W., Yuan, J. Death by deacetylation. Nature 492, 194–195 (2012). https://doi.org/10.1038/nature11761

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