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Molecular hurdles cleared with ease

Single-molecule studies reveal that a ring-like enzyme that encircles and 'slides' along one strand of duplex DNA, separating it from the other strand, overcomes molecular barriers in its path by transiently opening its ring. See Article p.205

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Figure 1: Mechanism of DNA unwinding by the large T antigen of simian virus 40.


  1. *This article and the paper under discussion1 were published online on 28 November 2012.


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Correspondence to Michael A. Trakselis.

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Trakselis, M., Graham, B. Molecular hurdles cleared with ease. Nature 492, 195–197 (2012).

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