Exposure to abnormal light–dark cycles causes depression-like behaviour and learning deficits in mice. The defects seem to occur independently of disturbances to sleep and other processes regulated by the biological clock. See Letter p.594
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*This article and the paper under discussion2 were published online on 14 November 2012.
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Monteggia, L., Kavalali, E. Depression brought to light. Nature 491, 537–538 (2012). https://doi.org/10.1038/nature11752
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DOI: https://doi.org/10.1038/nature11752
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