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Vascular biology

Nitric oxide caught in traffic

Nitric oxide is a vital signalling molecule that controls blood flow and pressure. Unexpectedly, a redox switch in the protein haemoglobin α within endothelial cells regulates this molecule's diffusion in blood vessels. See Letter p.473

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Figure 1: Regulation of nitric oxide (NO) diffusion by cytochrome b5 reductase 3.


  1. *This article and the paper under discussion1 were published online on 31 October 2012.


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Correspondence to Mark T. Gladwin.

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Gladwin, M., Kim-Shapiro, D. Nitric oxide caught in traffic. Nature 491, 344–345 (2012).

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