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Biochemistry

A glimpse of molecular competition

Single-molecule studies reveal how the DNA-repair protein RecA overcomes competition from another protein to bind to single-stranded DNA, and how other mediator proteins assist in this process. See Letter p.274

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Figure 1: Nucleation and extension of RecA filaments.

Notes

  1. *This article and the paper under discussion4 were published online on 24 October 2012.

References

  1. Persky, N. S. & Lovett, S. T. Crit. Rev. Biochem. Mol. Biol. 43, 347–370 (2008).

    Article  CAS  Google Scholar 

  2. Maher, R. L., Branagan, A. M. & Morrical, S. W. J. Cell. Biochem. 112, 2672–2682 (2011).

    Article  CAS  Google Scholar 

  3. Shereda, R. D., Kozlov, A. G., Lohman, T. M., Cox, M. M. & Keck, J. L. Crit. Rev. Biochem. Mol. Biol. 43, 289–318 (2008).

    Article  CAS  Google Scholar 

  4. Bell, J. C., Plank, J. L., Dombrowski, C. C. & Kowalczykowski, S. C. Nature 491, 274–278 (2012).

    Article  ADS  CAS  Google Scholar 

  5. Galletto, R., Amitani, I., Baskin, R. J. & Kowalczykowski, S. C. Nature 443, 875–878 (2006).

    Article  ADS  CAS  Google Scholar 

  6. Handa, N., Amitani, I., Gumlaw, N., Sandler, S. J. & Kowalczykowski, S. C. J. Biol. Chem. 284, 18664–18673 (2009).

    Article  CAS  Google Scholar 

  7. Hilario, J., Amitani, I., Baskin, R. J. & Kowalczykowski, S. C. Proc. Natl Acad. Sci. USA 106, 361–368 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Modesti, M. et al. Structure 15, 599–609 (2007).

    Article  CAS  Google Scholar 

  9. Shivashankar, G. V., Feingold, M., Krichevsky, O. & Libchaber, A. Proc. Natl Acad. Sci. USA 96, 7916–7921 (1999).

    Article  ADS  CAS  Google Scholar 

  10. van der Heijden, T. et al. Nucleic Acids Res. 35, 5646–5657 (2007).

    Article  CAS  Google Scholar 

  11. van Loenhout, M. T., van der Heijden, T., Kanaar, R., Wyman, C. & Dekker, C. Nucleic Acids Res. 37, 4089–4099 (2009).

    Article  CAS  Google Scholar 

  12. Joo, C. et al. Cell 126, 515–517 (2006).

    Article  CAS  Google Scholar 

  13. Morimatsu, K. & Kowalczykowski, S. C. Mol. Cell 11, 1337–1347 (2003).

    Article  CAS  Google Scholar 

  14. Umezu, K., Chi, N. W. & Kolodner, R. D. Proc. Natl Acad. Sci. USA 90, 3875–3879 (1993).

    Article  ADS  CAS  Google Scholar 

  15. Chen, Z., Yang, H. & Pavletich, N. P. Nature 453, 489–494 (2008).

    Article  ADS  CAS  Google Scholar 

  16. Kowalczykowski, S. C. Annu. Rev. Biophys. 20, 539–575 (1991).

    Article  CAS  Google Scholar 

  17. Thresher, R. J., Christiansen, G. & Griffith, J. D. J. Mol. Biol. 201, 101–113 (1988).

    Article  CAS  Google Scholar 

  18. Register, J. C. III & Griffith, J. J. Biol. Chem. 260, 12308–12312 (1985).

    CAS  PubMed  Google Scholar 

  19. Umezu, K. & Kolodner, R. D. J. Biol. Chem. 269, 30005–30013 (1994).

    CAS  PubMed  Google Scholar 

Download references

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Correspondence to Susan T. Lovett.

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Lovett, S. A glimpse of molecular competition. Nature 491, 198–200 (2012). https://doi.org/10.1038/nature11639

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