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Cancer therapy

Tumours switch to resist

Tumour cells can respond to targeted immune-cell therapies by losing proteins that mark them as being cancerous. Subverting this resistance mechanism may lead to more durable cancer-treatment strategies. See Letter p.412

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Figure 1: Escape by dedifferentiation.


  1. *This article and the paper under discussion1 were published online on 10 October 2012.


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Correspondence to Antoni Ribas.

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Ribas, A., Tumeh, P. Tumours switch to resist. Nature 490, 347–348 (2012).

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