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Neuroscience

Genes and human brain evolution

Several genes were duplicated during human evolution. It seems that one such duplication gave rise to a gene that may have helped to make human brains bigger and more adaptable than those of our ancestors.

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Figure 1: Evolution and function of a human gene.

References

  1. Konopka, G. et al. Nature 462, 213–217 (2009).

    CAS  Article  ADS  Google Scholar 

  2. Enard, W. et al. Cell 137, 961–971 (2009).

    CAS  Article  Google Scholar 

  3. Dennis, M. Y. et al. Cell 149, 912–922 (2012).

    CAS  Article  Google Scholar 

  4. Charrier, C. et al. Cell 149, 923–935 (2012).

    CAS  Article  Google Scholar 

  5. Guerrier, S. et al. Cell 138, 990–1004 (2009).

    CAS  Article  Google Scholar 

  6. Sudmant, P. H. et al. Science 330, 641–646 (2010).

    CAS  Article  ADS  Google Scholar 

  7. Elston, G. N., Benavides-Piccione, R. & DeFelipe, J. J. Neurosci. 21, RC163 (2001).

    CAS  Article  Google Scholar 

  8. Benavides-Piccione, R., Ballesteros-Yanez, I., DeFelipe, J. & Yuste, R. J. Neurocytol. 31, 337–346 (2002).

    Article  Google Scholar 

  9. Preuss, T. M., Cáceres, M., Oldham, M. C. & Geschwind, D. H. Nature Rev. Genet. 5, 850–860 (2004).

    CAS  Article  Google Scholar 

  10. Petanjek, Z. et al. Proc. Natl Acad. Sci. USA 108, 13281–13286 (2011).

    CAS  Article  ADS  Google Scholar 

  11. Somel, M. et al. Proc. Natl Acad. Sci. USA 106, 5743–5748 (2009).

    CAS  Article  ADS  Google Scholar 

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Correspondence to Daniel H. Geschwind or Genevieve Konopka.

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Geschwind, D., Konopka, G. Genes and human brain evolution. Nature 486, 481–482 (2012). https://doi.org/10.1038/nature11380

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