Debates over the role of sirtuin proteins in ageing are maturing into functional assessments of the individual proteins. It seems that overexpression of a specific sirtuin can extend lifespan in male mice. See Letter p.218
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*This article and the paper3 under discussion were published online on 22 February 2012.
Kaeberlein, M., McVey, M. & Guarente, L. Genes Dev. 13, 2570–2580 (1999).
Finkel, T., Deng, C.-X. & Mostoslavsky, R. Nature 460, 587–590 (2009).
Kanfi, Y. et al. Nature 483, 218–221 (2012).
Weindruch, R. & Sohal, R. S. N. Engl. J. Med. 337, 986–994 (1997).
Bartke, A. Phil. Trans. R. Soc. Lond. B 366, 28–34 (2011).
Ladiges, W. et al. Aging Cell 8, 346–352 (2009).
Xiao, C. et al. J. Biol. Chem. 285, 36776–36784 (2010).
Guevara-Aguirre, J. et al. Sci. Transl. Med. 3, 70ra13 (2011).
Muzumdar, R. et al. Aging Cell 7, 438–440 (2008).
Mao, Z. et al. Science 332, 1443–1446 (2011).
Kawahara, T. L. A. et al. Cell 136, 62–74 (2009).
Zhong, L. et al. Cell 140, 280–293 (2010).
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Lombard, D., Miller, R. Sorting out the sirtuins. Nature 483, 166–167 (2012). https://doi.org/10.1038/nature10950