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Sorting out the sirtuins

Debates over the role of sirtuin proteins in ageing are maturing into functional assessments of the individual proteins. It seems that overexpression of a specific sirtuin can extend lifespan in male mice. See Letter p.218

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Figure 1: Potential mechanisms of action of SIRT6 on longevity.


  1. *This article and the paper3 under discussion were published online on 22 February 2012.


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Correspondence to David B. Lombard or Richard A. Miller.

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Lombard, D., Miller, R. Sorting out the sirtuins. Nature 483, 166–167 (2012).

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