Figure 4 : Disruption of CADM2 and the PTEN pathway by rearrangements.

From: The genomic complexity of primary human prostate cancer

Figure 4

a, Location of intragenic breakpoints in CADM2. b, CADM2 break-apart demonstrated by FISH in an independent prostate tumour. c, Location of intragenic breakpoints in PTEN (top) and MAGI2 (bottom). d, MAGI2 inversion demonstrated by FISH in an independent prostate tumour, using probes flanking MAGI2 (red and green) and an external reference probe also on chromosome 7q (green). The probes and strategy for detecting novel rearrangements by FISH are shown in diagram form in Supplementary Fig. 8.