Kaplan et al. reply

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Abstract

Replying to: M. R. Dawson et al. Nature 461, 10.1038/nature08254 (2009)

Commenting on ref. 1, Dawson et al.2 claim that metastasis formation is independent of VEGFR1 activity, contradicting work by us and many others, including the original description of flt1TK-/- (VEGFR1-TK-/-) mice in the metastatic setting3. Contrasting the findings by Dawson et al.2, here we show that VEGFR1 knockdown in myelomonocytic cells eradicates micro- and macrometastases in a non-amputation/resection tumour model.

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Figure 1: Knockdown of VEGFR1 in the bone marrow inhibits metastatic progression.

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