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Emerging roles for lipids in shaping membrane-protein function

Nature volume 459, pages 379–385 (2009)Cite this article

Abstract

Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.

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Figure 1: Ion-channel function and membrane properties.
Figure 2: Geometry, deformations and energies of dilute and crowded membranes.
Figure 3: Structure and energy at the protein–lipid interface.
Figure 4: Membrane-protein interactions and conformational state.

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Acknowledgements

We are grateful to many people for insights and comments. In particular, we thank O. Andersen, M. Bialecka, F. Brown, N. Dan, L. Haswell, S. Johnson, J. Kondev, R. MacKinnon, C. Morris, D. Rees, D. Reeves, F. Sachs, D. Schmidt, S. Scheuring, S. Sukharev, M. Turner, S. White and M. Widom. We are also grateful to several anonymous reviewers for insightful comments. In addition, we are grateful to the US National Science Foundation and the National Institutes of Health for support through NIH Award number R01 GM084211 and the Director's Pioneer Award. The reference list for this article was constrained by length limits, and as a result the references cited here are representative rather than comprehensive. We apologize to those whose references are not cited as a result of either space limitations or our ignorance.

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Authors and Affiliations

  1. Department of Applied Physics, California Institute of Technology, Pasadena, 91125, California, USA

    Rob Phillips & Tristan Ursell

  2. Whitehead Institute of Biomedical Research, Cambridge, 02142, Massachusetts, USA

    Paul Wiggins

  3. UMR Gulliver CNRS-ESPCI, Paris, 7083, France

    Pierre Sens

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Correspondence should be addressed to R.P. (phillips@pboc.caltech.edu).

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Phillips, R., Ursell, T., Wiggins, P. et al. Emerging roles for lipids in shaping membrane-protein function. Nature 459, 379–385 (2009). https://doi.org/10.1038/nature08147

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