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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Nature volume 458, pages 445452 (26 March 2009) | Download Citation

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Abstract

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be transported to the lysosome lumen by the multivesicular endosome pathway. The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes. Then, through a highly conserved mechanism also used in cytokinesis and viral budding, it mediates the breaking off of the cargo-containing intraluminal vesicles from the perimeter membrane. The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell.

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Acknowledgements

C.R. is a postdoctoral fellow of the Norwegian Cancer Society. We also thank the Research Council of Norway, the Novo-Nordisk Foundation and the Hartmann Family Foundation for supporting our research.

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Affiliations

  1. Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway.

    • Camilla Raiborg
    •  & Harald Stenmark
  2. Department of Biochemistry, Institute for Cancer Research, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway.

    • Camilla Raiborg
    •  & Harald Stenmark

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Competing interests

The authors declare no competing financial interests.

Reprints and permissions information is available at http://www.nature.com/reprints.

Correspondence should be addressed to H.S. (stenmark@ulrik.uio.no).

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