Zhou et al. reply

Abstract

Replying to: C. H. Cotton, J. Flint & T. G. Campbell Nature 458, 10.1038/nature07927 (2009)

The inability of Cotton et al.1 to detect an effect of a functional haplotype (and locus) of neuropeptide Y (NPY), a stress regulatory neuropeptide, on neuroticism is interesting. Although it is important to measure effects of functional loci on complex behaviours, the strength of our study2, and primary basis of its conclusions, was the larger and convergent effects of NPY on intermediate phenotypes, including regional brain responses to emotional stimuli and pain, and brain NPY messenger RNA and plasma NPY levels. Eysenck Neuroticism is a trait that we did not directly investigate. We reported modest association of NPY with two Harm Avoidance subscales from the Tridimensional Personality Questionnaire. Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results.

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References

  1. 1

    Cotton, C. H., Flint, J. & Campbell, T. G. Is there an association between NPY and neuroticism? Nature 458 10.1038/nature07927 (2009)

  2. 2

    Zhou, Z. et al. Genetic variation in human NPY expression affects stress response and emotion. Nature 452, 997–1001 (2008)

  3. 3

    Shifman, S. et al. A whole genome association study of neuroticism using DNA pooling. Mol. Psychiatry 13, 302–312 (2008)

  4. 4

    Sirota, L. A., Greenberg, B. D., Murphy, D. L. & Hamer, D. H. Non-linear association between the serotonin transporter promoter polymorphism and neuroticism: a caution against using extreme samples to identify quantitative trait loci. Psychiatr. Genet. 9, 35–38 (1999)

  5. 5

    Hariri, A. R. et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400–403 (2002)

  6. 6

    Pezawas, L. et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neurosci. 8, 828–834 (2005)

  7. 7

    Egan, M. F. et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl Acad. Sci. USA 98, 6917–6922 (2001)

  8. 8

    Zubieta, J.-K. et al. COMT val158met genotype affects μ-opioid neurotransmitter responses to a pain stressor. Science 299, 1240–1243 (2003)

  9. 9

    Smolka, M. N. et al. Catechol-O-methyltransferase valmet genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J. Neurosci. 25, 836–842 (2005)

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Zhou, Z., Zhu, G., Hariri, A. et al. Zhou et al. reply. Nature 458, E7 (2009). https://doi.org/10.1038/nature07928

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