Commentary | Published:

A global network for investigating the genomic epidemiology of malaria

Nature volume 456, pages 732737 (11 December 2008) | Download Citation

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Abstract

Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease is greatest. The Malaria Genomic Epidemiology Network (MalariaGEN) is now working to overcome these obstacles, using a consortial approach that brings together researchers from 21 countries.

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Acknowledgements

MalariaGEN's primary funding is from the Wellcome Trust (grant number 077383/Z/05/Z) and from the Bill & Melinda Gates Foundation, through the Foundation for the National Institutes of Health (grant number 566) as part of the Grand Challenges in Global Health initiative. Initial work on the web-based software was funded by the Bill & Melinda Gates Foundation (grant number 29015) and the UK Medical Research Council (grant number G0200454). The Wellcome Trust (Sanger Institute core funding) and the Medical Research Council (grant number G0600230) provide additional support for genotyping, bioinformatics and analysis. We thank H. Pearson and colleagues at Bird & Bird for pro bono advice on intellectual property. The MalariaGEN Resource Centre is part of the European Union Network of Excellence on the Biology and Pathology of Malaria Parasites. Individuals who helped to establish MalariaGEN are acknowledged online (see http://www.malariagen.net/resource/1).

Author information

Affiliations

  1. The University of Buea, PO Box 63, Buea, South West Province, Cameroon

    • Eric Akum Achidi
    •  & Tobias O. Apinjoh
  2. Kwame Nkrumah University of Science and Technology, Private Mail Bag, Kumasi, Ghana.

    • Tsiri Agbenyega
    • , Jennifer Evans
    •  & Anthony Enimil
  3. Papua New Guinea Institute of Medical Research, PO Box 378, Madang, Papua New Guinea.

    • Stephen Allen
    • , Pascal Michon
    • , Ivo Mueller
    • , John Reeder
    • , Enmoore Lin
    •  & Laurens Manning
  4. Swansea Medical School, Swansea University, Singleton Park, Swansea, West Glamorgan SA2 8PP, UK.

    • Stephen Allen
  5. Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

    • Olukemi Amodu
  6. MRC Laboratories, Atlantic Road, Fajara, PO Box 273, Banjul, Gambia.

    • Kalifa Bojang
    • , David Conway
    • , Giorgio Sirugo
    •  & Muminatou Jallow
  7. National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

    • Patrick Corran
    •  & Paul Risley
  8. The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

    • Panos Deloukas
    • , Dominic Kwiatkowski
    • , Jane Rogers
    • , Taane Clark
    • , Daniel Alcock
    • , Sarah Auburn
    • , Susana Campino
    • , Katja Kivinen
    • , Bronwyn MacInnis
    • , Magnus Manske
    • , Gareth Maslen
    • , Aceme Nyika
    • , Elilan Somaskantharajah
    •  & Dominic Kwiatkowski (Chair)
  9. The Malaria Research & Training Centre, University of Bamako, PO Box 1805, Bamako, Mali.

    • Abdoulaye Djimde
    • , Amagana Dolo
    • , Ogobara Doumbo
    • , Mahamadou Thera
    • , Mahamadou Diakite
    • , Ousman Toure
    •  & Ogobara Duombo
  10. London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

    • Chris Drakeley
    • , Hugh Reyburn
    • , Eleanor Riley
    •  & Alphaxard Manjurano
  11. Joint Malaria Programme, Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania.

    • Chris Drakeley
    • , Hugh Reyburn
    •  & Alphaxard Manjurano
  12. Genome Science Center, Sokoine University of Agriculture, PO Box 3000, Chuo Kikuu, Morogoro, Tanzania.

    • Patrick Duffy
    •  & Theonest Mutabingwa
  13. Seattle Biomedical Research Institute, 307 Westlake Avenue North, Seattle, Washington 98109, USA.

    • Patrick Duffy
  14. Oxford University Clinical Research Unit, The Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam.

    • Sarah Dunstan
    • , Jeremy Farrar
    • , Tran Tinh Hien
    •  & Nguyen T. N. Quyen
  15. Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Postfach 30 41 2, D-20324 Hamburg, Germany.

    • Jennifer Evans
    •  & Rolf Horstmann
  16. Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo 8, Sri Lanka.

    • Deepika Fernando
    • , Nadira Karunaweera
    •  & Rajika Dewasurendra
  17. Institute of Endemic Disease, University of Khartoum, Medical Service Science Campus, PO Box 102, Khartoum, Sudan.

    • Muntaser Ibrahim
    • , Ayman Hussein
    •  & Abier Elzein
  18. Kenya Medical Research Institute (KEMRI)–Wellcome Trust Programme, PO Box 230, Kilifi, Kenya.

    • Gilbert Kokwaro
    • , Kevin Marsh
    • , Norbert Peshu
    • , Tom Williams
    • , Carolyne M. Ndila
    •  & Tom Oluoch
  19. Noguchi Memorial Institute for Medical Research, University of Ghana, PO Box LG 581, Accra, Ghana.

    • Kojo Koram
    • , Michael Wilson
    • , Lucas Amenga-Etego
    •  & Anita Ghansah
  20. Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

    • Dominic Kwiatkowski
    • , Jiannis Ragoussis
    • , Valentina D. Mangano
    • , Kirk A. Rockett
    • , Aaron Vanderwal
    • , Taane Clark
    • , Michael Parker
    • , Rebecca Wrigley
    • , David Barnwell
    • , Susan Bull
    • , Jantina deVries
    • , Abier Elzein
    • , Julie Evans
    • , Kathryn Fitzpatrick
    • , Anita Ghansah
    • , Angie Green
    • , Lee Hart
    • , Eliza Hilton
    • , Christina Hubbart
    • , Catherine Hughes
    • , Anna E. Jeffreys
    • , Marilyn McCreight
    • , Alieu Mendy
    • , Catherine Moyes
    • , Claire Potter
    • , Kate Rowlands
    • , Miguel SanJoaquin
    • , Kerrin Small
    • , Marryat Stevens
    • , YikYing Teo
    • , Renee Watson
    •  & Dominic Kwiatkowski (Chair)
  21. National Institute for Medical Research, PO Box 9653, Dar es Salaam, Tanzania.

    • Martha Lemnge
    •  & Deus Ishengoma
  22. Muhimbili University of Health and Allied Sciences, PO Box 65001, Dar es Salaam, Tanzania.

    • Julie Makani
  23. University of Rome 'La Sapienza', Piazzale Aldo Moro 5, 00185 Rome, Italy.

    • David Modiano
    •  & Valentina D. Mangano
  24. Malawi– Liverpool–Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, PO Box 30096, Chichiri, Blantyre 3, Malawi.

    • Malcolm E. Molyneux
    • , Vysaul Nyirongo
    •  & Miguel SanJoaquin
  25. The Ethox Centre, Department of Public Health and Primary Health Care, University of Oxford, Badenoch Building, Old Road Campus, Headington, Oxford OX3 7LF, UK.

    • Michael Parker
    • , Susan Bull
    •  & Jantina deVries
  26. Blantyre Malaria Project, PO Box 32256, Chichiri, Blantyre 3, Malawi.

    • Chris Plowe
    •  & Terrie Taylor
  27. University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA.

    • Chris Plowe
  28. Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France.

    • Odile Puijalon
    •  & Anavaj Sakuntabhai
  29. Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand.

    • Pratap Singhasivanon
  30. Centre National de Recherche et Formation sur le Paludisme, Avenue de l'Oubritenga, BP 2208, Ouagadougou 01, Burkina Faso.

    • Sodiomon Sirima
    •  & Edith Bougouma
  31. lnstitut Pasteur de Dakar, BP 220 Dakar, Senegal.

    • Adama Tall
    •  & Alioune Ly
  32. Michigan State University, Department of Internal Medicine, College of Osteopathic Medicine, East Lansing, Michigan 48825, USA.

    • Terrie Taylor
  33. The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.

    • Marita Troye-Blomberg
  34. Navrongo Health Research Centre, PO Box 114, Navrongo, Ghana.

    • Lucas Amenga-Etego
  35. Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok road, Siriraj, Bangkoknoi, Bangkok 10700, Thailand.

    • Prapat Suriyaphol
  36. Foundation for the National Institutes of Health, 9650 Rockville Pike, Bethesda, Maryland 20814, USA.

    • Dan Carucci
    •  & Michael Gottlieb
  37. The Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE, UK.

    • Katharine Cook
    •  & Alan Doyle

Consortia

  1. The Malaria Genomic Epidemiology Network

    Lead Investigators

    Data Fellows

    Resource Centre

    Project Management Committee

Authors

    Competing interests

    The author declare no competing financial interests.

    Reprints and permissions information is available at http://www.nature.com/reprints.

    Correspondence should be addressed to Dominic Kwiatkowski (dominic@sanger.ac.uk).

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    DOI

    https://doi.org/10.1038/nature07632

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