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The advent and development of organocatalysis

Nature volume 455, pages 304308 (18 September 2008) | Download Citation

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Abstract

The use of small organic molecules as catalysts has been known for more than a century. But only in the past decade has organocatalysis become a thriving area of general concepts and widely applicable asymmetric reactions. Here I present my opinion on why the field of organocatalysis has blossomed so dramatically over the past decade.

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Acknowledgements

I thank the National Institute of General Medical Sciences (grant number R01 GM078201-01-01) for financial support, and Merck Research Laboratories and Bristol-Myers Squibb for gifts. I also thank H. Kim, R. Knowles, D. Carerra and J. Van Humbeck for their help in the preparation of the manuscript.

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Affiliations

  1. David W. C. MacMillan is at the Merck Center for Catalysis at Princeton University, 116 Frick Laboratory, Princeton University, Princeton, New Jersey 08540, USA.

    • David W. C. MacMillan

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Competing interests

The author declares no competing financial interests.

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Correspondence should be addressed to the author (dmacmill@princeton.edu).

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https://doi.org/10.1038/nature07367

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