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Maternal nodal and zebrafish embryogenesis

A Brief Communications Arising to this article was published on 08 November 2007


Arising from: A. V. Gore et al. Nature 438, 1030–1035 (2005)10.1038/nature04184; Gore et al. reply

In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway1,2. Gore et al.3 suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.

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Figure 1: Splicing and disruption of sqt RNA.
Figure 2: The maternal Nodal genes cyclops and squint are not required for dorsal axis specification.

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Bennett, J., Stickney, H., Choi, WY. et al. Maternal nodal and zebrafish embryogenesis. Nature 450, E1–E2 (2007).

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