Brief Communications Arising | Published:

Maternal nodal and zebrafish embryogenesis

Nature volume 450, pages E1E2 (08 November 2007) | Download Citation


Arising from: A. V. Gore et al. Nature 438, 1030–1035 (2005)10.1038/nature04184; Gore et al. reply

In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway1,2. Gore et al.3 suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.

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Author information


  1. *Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA

    • James T. Bennett
    • , Wen-Yee Choi
    • , Brian Ciruna
    •  & Alexander F. Schier
  2. †Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA

    • James T. Bennett
    • , Wen-Yee Choi
    • , Brian Ciruna
    •  & Alexander F. Schier
  3. ‡Department of Developmental Biology, Stanford University, Stanford, California 94305, USA

    • Heather L. Stickney
    •  & William S. Talbot
  4. §Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Center for Brain Science, Broad Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

    • Wen-Yee Choi
    •  & Alexander F. Schier
  5. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

    • Brian Ciruna
  6. ¶The Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada

    • Brian Ciruna


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