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Autoimmune disease

Skin deep but complex

The antimicrobial peptide LL37 is essential for normal immune responses to infection or tissue injury. But in the autoimmune skin disorder psoriasis, LL37 propagates disease by forming complexes with host DNA.

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Figure 1: Role of LL37 in psoriasis.


  1. This article and the paper concerned1 were published online on 16 September 2007.


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Baumgarth, N., Bevins, C. Skin deep but complex. Nature 449, 551–553 (2007).

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