Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Chemical Biology

Ignore the nonsense

A small molecule forces the protein-translation machinery to overlook the signals that would otherwise result in its premature termination. Genuine stop signs are, however, read and obeyed.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Possible mechanisms of PTC124-enhanced translation.


  1. This article and the paper concerned1 were published online on 22 April 2007.


  1. Welch, E. M. et al. Nature 447, 87–91 (2007).

    ADS  CAS  Article  Google Scholar 

  2. Howard, M., Frizzell, R. A. & Bedwell, D. M. Nature Med. 2, 467–469 (1996).

    CAS  Article  Google Scholar 


  4. Ainsworth, C. Nature 438, 726–728 (2005).

    ADS  CAS  Article  Google Scholar 

  5. Hamed, S. A. IDrugs 9, 783–789 (2006).

    CAS  PubMed  Google Scholar 

  6. Chang, Y.-F., Imam, J. S. & Wilkinson, M. F. Annu. Rev. Biochem. 76, doi:10.1146/annurev.biochem.76.050106.093909 (2007).

  7. Ishigaki, Y., Li, X., Serin, G. & Maquat, L. E. Cell 106, 607–617 (2001).

    CAS  Article  Google Scholar 

  8. Nagy, E. & Maquat, L. E. Trends Biochem. Sci. 23, 198–199 (1998).

    CAS  Article  Google Scholar 

  9. Lelivelt, M. J. & Culbertson, M. R. Mol. Cell. Biol. 19, 6710–6719 (1999).

    CAS  Article  Google Scholar 

  10. He, F. et al. Mol. Cell 12, 1439–1452 (2003).

    CAS  Article  Google Scholar 

  11. Mendell, J. T., Sharifi, N. A., Meyers, J. L., Martinez-Murillo, F. & Dietz, H. C. Nature Genet. 36, 1073–1078 (2004).

    CAS  Article  Google Scholar 

  12. Mitrovich, Q. M. & Anderson, P. Curr. Biol. 15, 963–967 (2005).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schmitz, A., Famulok, M. Ignore the nonsense. Nature 447, 42–43 (2007).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing