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Reducing the global burden of tuberculosis: the contribution of improved diagnostics

We estimated the impact of hypothetical new diagnostic tests for tuberculosis (TB) in patients with persistent cough in developing countries. We found that a variety of new tests could help better identify TB cases and target treatment, thereby reducing the burden of disease.

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Figure 1: Tree for adults presenting with persistent cough.
Figure 2: Sensitivity and specificity tradeoffs in new tests.
Figure 3: Impact of a 0.01 change in parameters on lives gained (in thousands) in southeast Asia.

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Acknowledgements

The authors thank M. Weinstein (Harvard School of Public Health, Massachusetts, USA) and M. Zignol (World Health Organization, Geneva, Switzerland) for their comments on an earlier draft of this paper.

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Correspondence to Emmett Keeler.

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Keeler, E., Perkins, M., Small, P. et al. Reducing the global burden of tuberculosis: the contribution of improved diagnostics. Nature 444 (Suppl 1), 49–57 (2006). https://doi.org/10.1038/nature05446

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