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Reducing the global burden of tuberculosis: the contribution of improved diagnostics

We estimated the impact of hypothetical new diagnostic tests for tuberculosis (TB) in patients with persistent cough in developing countries. We found that a variety of new tests could help better identify TB cases and target treatment, thereby reducing the burden of disease.

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Figure 1: Tree for adults presenting with persistent cough.
Figure 2: Sensitivity and specificity tradeoffs in new tests.
Figure 3: Impact of a 0.01 change in parameters on lives gained (in thousands) in southeast Asia.


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The authors thank M. Weinstein (Harvard School of Public Health, Massachusetts, USA) and M. Zignol (World Health Organization, Geneva, Switzerland) for their comments on an earlier draft of this paper.

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Correspondence to Emmett Keeler.

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Keeler, E., Perkins, M., Small, P. et al. Reducing the global burden of tuberculosis: the contribution of improved diagnostics. Nature 444 (Suppl 1), 49–57 (2006).

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