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Structural biology

Dangerous liaisons on neurons

Crystal structures show that botulinum toxins bind simultaneously to two sites on neurons. This dual interaction allows them to use a Trojan-horse strategy to enter nerve terminals, with deadly effect.

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Figure 1: Possible binding sites of botulinum neurotoxin B (BoNT/B) on neurons.


  1. This article and the papers concerned1,2 were published online on 13 December 2006.


  1. Jin, R., Rummel, A., Binz, T. & Brunger, A. T. Nature 444, 1092–1095 (2006).

    Article  ADS  CAS  Google Scholar 

  2. Chai, Q. et al. Nature 444, 1096–1100 (2006).

    Article  ADS  CAS  Google Scholar 

  3. Schiavo, G., Matteoli, M. & Montecucco, C. Physiol. Rev. 80, 717–766 (2000).

    Article  CAS  Google Scholar 

  4. Montecucco, C. Trends Biochem. Sci. 11, 314–317 (1986).

    Article  CAS  Google Scholar 

  5. Nishiki, T. et al. FEBS Lett. 378, 253–257 (1996).

    Article  CAS  Google Scholar 

  6. Dong, M. et al. J. Cell Biol. 162, 1293–1303 (2003).

    Article  CAS  Google Scholar 

  7. Rummel, A., Karnath, T., Henke, T., Bigalke, H. & Binz, T. J. Biol. Chem. 279, 30865–30870 (2004).

    Article  CAS  Google Scholar 

  8. Dong, M. et al. Science 312, 592–596 (2006).

    Article  ADS  CAS  Google Scholar 

  9. Mahrhold, S., Rummel, A., Bigalke, H., Davletov, B. & Binz, T. FEBS Lett. 580, 2011–2014 (2006).

    Article  CAS  Google Scholar 

  10. Rummel, A. et al. Proc. Natl Acad. Sci. USA (in the press).

  11. Fernandez-Alfonso, T., Kwan, R. & Ryan, T. A. Neuron 51, 149–151 (2006).

    Article  Google Scholar 

  12. Deinhardt, K., Berninghausen, O., Willison, H. J., Hopkins, C. R. & Schiavo, G. J. Cell Biol. 174, 459–471 (2006).

    Article  CAS  Google Scholar 

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Schiavo, G. Dangerous liaisons on neurons. Nature 444, 1019–1020 (2006).

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