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Structural biology

Enzyme target to latch on to

Nature volume 443, pages 761762 (19 October 2006) | Download Citation

Subjects

Insulin-degrading enzyme is implicated in diabetes and Alzheimer's disease, but few molecular tools exist that can probe its function. A study now reveals its unusual structure and may lead to an expanded toolbox.

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Author information

Affiliations

  1. Malcolm A. Leissring is in the Department of Biochemistry, Scripps Florida, The Scripps Research Institute, Jupiter, Florida 33458, USA. leissring@scripps.edu

    • Malcolm A. Leissring
  2. Dennis J. Selkoe is at the Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. dselkoe@rics.bwh.harvard.edu

    • Dennis J. Selkoe

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DOI

https://doi.org/10.1038/nature05210

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