It's not clear what general level of accuracy is required in translating the genetic code. But the protective role of proof-reading is evident from a case in which a small mistake has a catastrophic effect.
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Notes
*This article and the paper concerned2 were published online on 13 August 2006.
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Roy, H., Ibba, M. Sticky end in protein synthesis. Nature 443, 41–42 (2006). https://doi.org/10.1038/nature05002
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DOI: https://doi.org/10.1038/nature05002
