Brief Communications Arising | Published:

Immunology

Toll-like receptors and antibody responses (Reply)

Naturevolume 441pageE4 (2006) | Download Citation

Subjects

Abstract

Using a range of different experimental approaches (and not just analyses of MyD88-deficient mice), we showed that, contrary to the prevailing view, a T-helper response is not sufficient for the generation of optimal T-dependent antibody responses, and that Toll-like-receptor (TLR) signalling in B cells is also required1. Similar results have since been obtained in human B cells2. Nemazee et al.3 now question our conclusions1.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Pasare, C. & Medzhitov, R. Nature 438, 364–368 (2005).

  2. 2

    Ruprecht, C. R. & Lanzavecchia, A. Eur. J. Immunol. 36, 810–816 (2006).

  3. 3

    Nemazee, D., Gavin, A., Hoebe, K. & Beutler, B. Nature 441, doi:10.1038/nature04875 (2006).

Download references

Author information

Affiliations

  1. Howard Hughes Medical Institute and Section of Immunology, Yale University School of Medicine, New Haven, 06510, Connecticut, USA

    • C. Pasare
    •  & R. Medzhitov

Authors

  1. Search for C. Pasare in:

  2. Search for R. Medzhitov in:

Corresponding author

Correspondence to R. Medzhitov.

About this article

Publication history

Published

Issue Date

DOI

https://doi.org/10.1038/nature04876

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.