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Measurement of the conductance of single conjugated molecules

An Erratum to this article was published on 25 August 2005


Electrical conduction through molecules depends critically on the delocalization of the molecular electronic orbitals and their connection to the metallic contacts. Thiolated (- SH) conjugated organic molecules are therefore considered good candidates for molecular conductors1,2: in such molecules, the orbitals are delocalized throughout the molecular backbone, with substantial weight on the sulphur–metal bonds1,2,3,4. However, their relatively small size, typically 1 nm, calls for innovative approaches to realize a functioning single-molecule device5,6,7,8,9,10,11. Here we report an approach for contacting a single molecule, and use it to study the effect of localizing groups within a conjugated molecule on the electrical conduction. Our method is based on synthesizing a dimer structure, consisting of two colloidal gold particles connected by a dithiolated short organic molecule12,13, and electrostatically trapping it between two metal electrodes. We study the electrical conduction through three short organic molecules: 4,4′-biphenyldithiol (BPD), a fully conjugated molecule; bis-(4-mercaptophenyl)-ether (BPE)14, in which the conjugation is broken at the centre by an oxygen atom; and 1,4-benzenedimethanethiol (BDMT), in which the conjugation is broken near the contacts by a methylene group. We find that the oxygen in BPE and the methylene groups in BDMT both suppress the electrical conduction relative to that in BPD.

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Figure 1: The molecules and colloidal structures under study.
Figure 2: Image and low-temperature differential conductance spectra of dimers.
Figure 3: Temporal fluctuations and temperature dependence of the dimer conductance.
Figure 4: The reproducibility of the conductance spectra measurements of different BPD dimers.


  1. Nitzan, A. & Ratner, M. A. Electron transport in molecular wire junctions. Science 300, 1384–1389 (2003)

    ADS  CAS  Article  Google Scholar 

  2. Joachim, C., Gimzewski, J. K. & Aviram, A. Electronics using hybrid-molecular and mono-molecular devices. Nature 408, 541–548 (2000)

    ADS  CAS  Article  Google Scholar 

  3. Xue, Y. & Ratner, M. A. Microscopic study of electrical transport through individual molecules with metallic contacts. I. Band lineup, voltage drop, and high-field transport. Phys. Rev. B 68, 115406–115418 (2003)

    ADS  Article  Google Scholar 

  4. Remacle, F. & Levine, R. D. Electrical transmission of molecular bridges. Chem. Phys. Lett. 383, 537–543 (2004)

    ADS  CAS  Article  Google Scholar 

  5. Reed, M. A., Zhou, C., Muller, C. J., Burgin, T. P. & Tour, J. M. Conductance of a molecular junction. Science 278, 252–254 (1997)

    CAS  Article  Google Scholar 

  6. Reichert, J. et al. Driving current through single organic molecules. Phys. Rev. Lett. 88, 176804 (2002)

    ADS  CAS  Article  Google Scholar 

  7. Smit, R. H. M. et al. Measurement of the conductance of a hydrogen molecule. Nature 419, 906–909 (2002)

    ADS  CAS  Article  Google Scholar 

  8. Park, H., Lim, A. K. L., Alivisatos, A. P., Park, J. & McEuen, P. L. Fabrication of metallic electrodes with nanometer separation by electromigration. Appl. Phys. Lett. 75, 301–303 (1999)

    ADS  CAS  Article  Google Scholar 

  9. Park, J. et al. Coulomb blockade and the Kondo effect in single-atom transistors. Nature 417, 722–725 (2002)

    ADS  CAS  Article  Google Scholar 

  10. Liang, W., Shores, M. P., Bockrath, M., Long, J. R. & Park, H. Kondo resonance in a single-molecule transistor. Nature 417, 725–729 (2002)

    ADS  CAS  Article  Google Scholar 

  11. Cui, X. D. et al. Reproducible measurement of single-molecule conductivity. Science 294, 571–574 (2001)

    ADS  CAS  Article  Google Scholar 

  12. Peng, X., Wilson, T. E., Alivisatos, A. P. & Schultz, P. G. Synthesis and isolation of a homodimer of cadmium selenide nanocrystals. Angew. Chem. Int. Edn Engl. 36, 145–147 (1997)

    CAS  Article  Google Scholar 

  13. Brousseau, L. C. III, Novak, J. P., Marinakos, S. M. & Feldheim, D. L. Assembly of phenylacetylene-bridged gold nanocluster dimers and trimers. Adv. Mater. 11, 447–449 (1999)

    CAS  Article  Google Scholar 

  14. Baron, A. L. & Blank, D. R. Synthesis and properties of some aromatic polythioethers. Makromol. Chem. 140, 83–89 (1970)

    CAS  Article  Google Scholar 

  15. Bezryadin, A., Dekker, C. & Schmid, G. Electrostatic trapping of single conducting nanoparticles between nanoelectrodes. Appl. Phys. Lett. 71, 1273–1275 (1997)

    ADS  CAS  Article  Google Scholar 

  16. Krahne, R. et al. Fabrication of nanoscale gaps in integrated circuits. Appl. Phys. Lett. 81, 730–732 (2002)

    ADS  CAS  Article  Google Scholar 

  17. Park, H. et al. Nanomechanical oscillations in a single-C60 transistor. Nature 407, 57–60 (2000)

    ADS  CAS  Article  Google Scholar 

  18. Grabar, K. C. et al. Two-dimensional arrays of colloidal gold particles: A flexible approach to macroscopic metal surfaces. Langmuir 12, 2353–2361 (1996)

    CAS  Article  Google Scholar 

  19. Weisbecker, C. S., Merritt, M. V. & Whitesides, G. M. Molecular self-assembly of aliphatic thiols on gold colloids. Langmuir 12, 3763–3772 (1996)

    CAS  Article  Google Scholar 

  20. Xu, H. X., Bjerneld, E. J., Kall, M. & Borjesson, L. Spectroscopy of single hemoglobin molecules by surface enhanced Raman scattering. Phys. Rev. Lett. 83, 4357–4360 (1999)

    ADS  CAS  Article  Google Scholar 

  21. Amlani, I., Rawlett, A. M., Nagahara, L. A. & Tsui, R. K. An approach to transport measurements of electronic molecules. Appl. Phys. Lett. 80, 2761–2763 (2002)

    ADS  CAS  Article  Google Scholar 

  22. Ron, H., Matlis, S. & Rubinstein, I. Self-assembled monolayers on oxidized metals. 2. Gold surface oxidative pretreatment, monolayer properties, and depression formation. Langmuir 14, 1116–1121 (1998)

    CAS  Article  Google Scholar 

  23. Hazani, M. et al. DNA-mediated self-assembly of carbon nanotube-based electronic devices. Chem. Phys. Lett. 391, 389–392 (2004)

    ADS  CAS  Article  Google Scholar 

  24. Grabert, H. & Devoret, M. H. (eds) Single Charge Tunneling: Coulomb Blockade Phenomena in Nanostructures (NATO ASI Ser. B. Vol. 294, Plenum, New York, 1992)

  25. Xiao, X. Y., Xu, B. Q. & Tao, N. J. Measurement of single molecule conductance: Benzenedithiol and benzenedimethanethiol. Nano Lett. 4, 267–271 (2004)

    ADS  CAS  Article  Google Scholar 

  26. Lee, J. O. et al. Absence of strong gate effects in electrical measurements on phenylene-based conjugated molecules. Nano Lett. 3, 113–117 (2003)

    ADS  CAS  Article  Google Scholar 

  27. Zhu, T., Vasilev, K., Kreiter, M., Mittler, S. & Knoll, W. Surface modification of citrate-reduced colloidal gold nanoparticles with 2-mercaptosuccinic acid. Langmuir 19, 9518–9525 (2003)

    CAS  Article  Google Scholar 

  28. Handley, D. A. in Colloidal Gold—Principles, Methods, and Applications (ed. Hayat, M. A.) 13–32 (Academic, New York, 1989)

    Google Scholar 

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This work was supported by the Minerva foundation. We thank R. Popovitz for assistance in obtaining the TEM image (Fig. 1f).

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Correspondence to Israel Bar-Joseph.

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Reprints and permissions information is available at The authors declare no competing financial interests.

Supplementary information

Supplementary Figure S1

Measurements of the conductance of single colloids shown in the Vds-Vg plane. (PDF 4836 kb)

Supplementary Figure S2

A comparison between the conductance spectra of a single colloid and a dimer. (PDF 1516 kb)

Supplementary Figures Legends

Text to accompany the above Supplementary Figures. (DOC 19 kb)

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Dadosh, T., Gordin, Y., Krahne, R. et al. Measurement of the conductance of single conjugated molecules. Nature 436, 677–680 (2005).

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