Robust habit learning in the absence of awareness and independent of the medial temporal lobe

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Abstract

Habit memory is thought to involve slowly acquired associations between stimuli and responses and to depend on the basal ganglia1. Habit memory has been well studied in experimental animals but is poorly understood in humans because of their strong tendency to acquire information as conscious (declarative) knowledge. Here we show that humans have a robust capacity for gradual trial-and-error learning that operates outside awareness for what is learned and independently of the medial temporal lobe. We tested two patients with large medial temporal lobe lesions and no capacity for declarative memory. Both patients gradually acquired a standard eight-pair object discrimination task over many weeks but at the start of each session could not describe the task, the instructions or the objects. The acquired knowledge was rigidly organized, and performance collapsed when the task format was altered.

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Figure 1: Magnetic resonance images showing the extent of damage to the temporal lobe in amnesic patients.
Figure 2: Performance on the concurrent discrimination task.

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Acknowledgements

We thank B. Suchan for assistance, and R. Clark and J. Wixted for discussion. This work was supported by the Medical Research Service of the Department of Veterans Affairs, an NIMH grant, and the Metropolitan Life Foundation.

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Correspondence to Larry R. Squire.

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Reprints and permissions information is available at npg.nature.com/reprintsandpermissions. The authors declare no competing financial interests.

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Supplementary Data

Estimates of brain damage for patients E.P. and G.P. based on quantitative analysis of magnetic resonance images. (DOC 20 kb)

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Bayley, P., Frascino, J. & Squire, L. Robust habit learning in the absence of awareness and independent of the medial temporal lobe. Nature 436, 550–553 (2005) doi:10.1038/nature03857

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